MT-2 (Melanotan 2 Acetate) 10mg

Important Note

This page is informational and does not authorize use. Peptify clients should complete assessment, disclose medications and health history, and follow the clinician-approved plan only.

Do not start, stop, combine, or change a protocol based only on website content.
Emergency symptoms require urgent medical care, not a website or routine follow-up message.

Quickstart Highlights

Melanotan II is a synthetic cyclic analog of alpha-melanocyte-stimulating hormone (α-MSH) that activates melanocortin receptors — chiefly MC1R (driving melanin production and skin tanning) and MC4R (linked to sexual arousal and appetite effects)[1][2]. It is not approved by any major regulator — an unapproved new drug sold as a research chemical. This educational page outlines a once-daily subcutaneous loading approach in micrograms, with a dilution chosen so doses land on easy-to-read insulin-syringe marks. Presented for research and educational use only.

Add 2.0 mL bacteriostatic water to one 10 mg vial → 5 mg/mL (5,000 mcg/mL), giving clean unit math on a U-100 syringe.
~250 mcg/day to start (some begin at 100 mcg to assess tolerance), titrated up as UVB exposure drives the tan.
At 5 mg/mL, 1 unit = 50 mcg; 250 mcg = 5 units (0.05 mL), 500 mcg = 10 units, 1 mg = 20 units on a U-100 syringe.
Lyophilized: store at −20 °C (−4 °F); once reconstituted, refrigerate at 2–8 °C (35.6–46.4 °F) and do not freeze the solution.
Important: Start with the Prep & Injection Guide — it covers the preparation and safety basics every protocol on this site assumes.

Dosing & Reconstitution Guide

A single practical dilution with accurate once-daily dosing, step by step

Standard / Loading Approach (2 mL = 5 mg/mL)

Phase / Week(s)	Dose & Frequency	Volume (U-100 units / mL)
Loading, Week 1	250 mcg (1× daily)	5 units (0.05 mL)
Loading, Week 2	500 mcg (1× daily)	10 units (0.10 mL)
Loading, Weeks 3–4	750 mcg (1× daily)	15 units (0.15 mL)
Loading, Weeks 5–8	1000 mcg / 1 mg (1× daily)	20 units (0.20 mL)
Maintenance (after Week 8)	500–1000 mcg (~1× weekly / as needed)	10–20 units (0.10–0.20 mL)

Reconstitute: Add 2.0 mL bacteriostatic water to one 10 mg vial → final concentration 5 mg/mL (5,000 mcg/mL).
Loading dose: Begin around 250 mcg/day (some start at 100 mcg) to assess tolerance, then titrate up over the loading phase as UVB exposure drives the tan.
Maintenance: After the tan is established, a maintenance dose of roughly 500–1000 mcg about 1× per week (or as needed) is used to sustain pigmentation.
Easy measuring: At 5 mg/mL, 1 unit = 50 mcg on a U-100 syringe (units = dose ÷ concentration). 250 mcg = 5 units, 500 mcg = 10 units, 1 mg = 20 units.
Storage: Lyophilized: store at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and do not freeze the mixed solution.
Frequency: one subcutaneous injection each day during the loading phase, titrating up as tolerated, then transitioning to a maintenance dose ~1× per week or as needed. UVB exposure is what actually drives the tan; the peptide increases the pigment response[3]. These figures come from reference protocols, not from approved human dosing.
Dose ceiling: do not exceed ~2 mg/day. Case reports describe serious systemic toxicity and rhabdomyolysis at mega-doses (around 6 mg)[4].

Reconstitution Steps

Draw 2.0 mL of bacteriostatic water into a sterile syringe.

Release it slowly down the vial’s inner wall to limit foaming.
Swirl or roll gently until fully dissolved — don’t shake.
Label with the date and concentration, then refrigerate at 2–8 °C (35.6–46.4 °F), shielded from light.
At 5 mg/mL, low loading doses read at just 5–10 units; a 30- or 50-unit insulin syringe can make these small volumes easier to read. Avoid freezing the reconstituted solution, since freeze–thaw can denature the peptide.
Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.

Supplies Needed

Quantities below assume an 8–16 week course: a daily loading phase followed by weekly maintenance.

A 10 mg vial covers roughly two weeks of loading at the ~1 mg/day plateau, then several weekly maintenance doses.
8 weeks: ~5 vials
12 weeks: ~8 vials
16 weeks: ~10 vials
Per injection: 1 syringe
8 weeks (loading daily): ~56 syringes
16 weeks (loading daily): ~112 syringes
Use 2.0 mL per 10 mg vial for reconstitution.
8 weeks (5 vials): ~10 mL → 1–2 bottles
16 weeks (10 vials): ~20 mL → 2 bottles
One for the vial stopper + one for the injection site each day.
Per injection: 2 swabs
8 weeks (loading daily): ~112 swabs → 1–2 boxes

Protocol Overview

A concise summary of the once-daily loading regimen, drawn from commonly cited reference protocols.

▪Goal: Increase skin pigmentation (tanning) via melanocortin (MC1R) receptor activation; MC4R activity also drives arousal and appetite effects[1].
▪Schedule: Daily subcutaneous injections for a 6–8 week loading phase, then maintenance dosing about 1× weekly (or as needed)[3].
▪Dose Range: ~250–1000 mcg per day during loading, titrated gradually to minimize side effects; do not exceed 2 mg/day.
▪Reconstitution: 2.0 mL bacteriostatic water per 10 mg vial gives 5 mg/mL for clean unit measurements.
▪Storage: Keep the dry vial frozen at −20 °C (−4 °F); once mixed, refrigerate at 2–8 °C and do not freeze the solution.

Dosing Protocol

A suggested daily titration approach based on common reference doses.

▪Start: Begin at ~250 mcg once daily (some start at 100 mcg) to gauge tolerability for nausea and flushing.
▪Titrate: Increase by roughly 100–250 mcg every 1–2 weeks as tolerated.
▪Target: Reach about 500–1000 mcg daily by Weeks 4–8; UVB exposure drives the tan.
▪Maintenance: After loading, ~500–1000 mcg about 1× per week (or as needed) sustains pigmentation.
▪Timing: Inject at a consistent time and rotate injection sites systematically.

Storage Instructions

Correct storage is what preserves the peptide’s stability and activity.

▪Lyophilized: Hold the dry vial at −20 °C (−4 °F) in dry, dark conditions and limit moisture exposure[7].
▪Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F) and use within about 1–2 weeks; do not freeze the mixed solution, as freezing can denature peptides[8].
▪Handling: Let frozen vials warm to room temperature before opening so condensation won’t form, and keep the solution clear of heat and direct light.
▪Freeze–thaw: Avoid repeated freeze–thaw cycles; prepare aliquots if longer storage is needed.

Important Notes

Practical points that keep administration safe and consistent.

▪Sterile technique: Use a fresh sterile U-100 insulin syringe each time and drop it straight into a puncture-proof sharps container afterward.
▪Site rotation: Move between abdomen, thighs and upper arms to reduce local irritation and lipohypertrophy[9].
▪Mole monitoring: Melanotan II can darken existing moles and freckles and prompt new pigmented spots; inspect skin regularly and seek dermatological review of any new or changing lesion — there are concerns about melanoma[6].
▪Dose discipline: Never exceed 2 mg/day; serious systemic toxicity and rhabdomyolysis have been reported at mega-doses (~6 mg)[4].
▪Regulatory note: Melanotan II is not approved by any major regulator — an unapproved new drug sold as a research chemical, not a medicine[6].

How This Works

Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) that binds and activates melanocortin receptors, particularly MC1R and MC4R[1].

Activation of MC1R on melanocytes stimulates melanin production and distribution, producing increased skin pigmentation. Activation of MC4R in the central nervous system is associated with the drug’s reported sexual-arousal and appetite-suppressing effects[2].
Early human work identified daily doses in the range of roughly 1–2 mg as producing measurable tanning, with conservative protocols starting much lower to limit nausea and flushing[1][2]. Pigmentation accumulates over the loading phase, and UVB exposure is the actual driver of the tan — the peptide amplifies the pigment response[3].
Important caveat: Melanotan II is not an approved medicine in any major jurisdiction. It is an unapproved new drug sold as a research chemical, presented here for research and educational purposes only. Because of its MC1R / pigment effects, there are specific concerns about the darkening of moles and the need to monitor for melanoma.

Lifestyle Factors

Habits that influence outcomes and safety alongside the protocol.

▪UV exposure: Melanotan II increases melanin, but UVB is what drives the tan; always use appropriate sun protection to reduce skin-cancer risk[6].
▪Hydration: Maintain adequate fluid intake, especially if experiencing nausea or appetite suppression.
▪Skin monitoring: Inspect moles and freckles regularly; seek dermatological evaluation if any new or changing pigmented lesions appear[6].
▪Dose discipline: Adhere strictly to conservative dosing; never exceed 2 mg/day to avoid serious adverse effects[4].
Observations from early clinical trials and case reports; human evidence is limited and individual results vary.
▪Increased pigmentation: Skin tanning via MC1R activation, typically observable after 5–10 daily injections[1].
▪Sexual arousal: MC4R activation can induce spontaneous erections / increased libido in men[5].
▪Appetite suppression: Reduced appetite is commonly reported, also an MC4R-mediated effect.
▪Note on approval: These effects come from unapproved use — Melanotan II is not approved by any major regulator.
▪Nausea & flushing: Dose-dependent nausea and facial flushing are the most common short-term effects[2].
▪Mole / freckle darkening: Existing moles and freckles can darken and new pigmented spots can appear; theoretical melanoma concerns warrant skin monitoring[6].
▪Dose-limiting toxicity: Severe sympathomimetic symptoms and rhabdomyolysis reported at a 6 mg dose[4].
▪Unapproved status: Not approved by any major regulator; long-term safety in humans is not established.

Injection Technique

General subcutaneous technique, following established clinical best-practice guidance[14].

▪Wash your hands well with soap and water.
▪Wipe the vial stopper with an alcohol swab and let it air-dry.
▪Choose a site (abdomen, thigh, or upper arm) and clean it with a fresh alcohol swab, letting it dry fully.
▪Draw the intended dose, then check for air bubbles and push any out.
▪Pinch a skinfold at the chosen site between thumb and forefinger.
▪Insert the needle into the pinch at a 45–90-degree angle (use 45 degrees if the fat layer is thin)[14].
▪Skip aspiration for subcutaneous shots — it isn’t needed[14].
▪Press the plunger slowly and steadily until it’s fully down.
▪Wait 5–10 seconds, then pull the needle straight out to prevent leakage.
▪Drop the used syringe straight into a puncture-proof sharps container — never recap a needle.
▪Return the reconstituted vial to the fridge right away.
▪Rotate the injection site each day to prevent irritation and lipohypertrophy[9].
▪Watch the site for excess redness, swelling, or signs of infection.

Recommended Source

For high-purity research peptides, we point researchers to Prime Lab Peptides for Melanotan II (10 mg).

▪Top-rated on Trustpilot: Independently reviewed as the highest-rated peptide lab on Trustpilot — making it the best current source in the USA. Open source
▪Third-party tested: Every batch ships with a Certificate of Analysis (COA) confirming purity and composition.
▪Consistent quality: ISO-aligned manufacturing and handling keep product integrity reliable batch to batch.
▪Cold-chain integrity: Temperature-controlled shipping and storage across the whole fulfilment chain.
▪Research-grade purity: Fit for educational and research use that demands high-quality peptides.
Note: Product availability and specifications subject to change. Verify current product details on supplier website.
Shop at Prime Lab Peptides →

References

Reference-derived details for MT-2 (Melanotan 2 Acetate) 10mg.

Melanotan II (10mg Vial) Dosage Protocol Open source
1 Journal of Clinical Endocrinology & Metabolism (PubMed) Phase I evaluation of Melanotan II, an α-MSH analog, for tanning and melanocortin receptor activation. View Source ↗ Open source
2 Peptides (PubMed) Melanotan II dose-finding and tolerability: tanning response with nausea and flushing at higher doses. View Source ↗ Open source
3 British Journal of Dermatology (PubMed) Afamelanotide / melanocortin analogs and UV-driven photoprotection and pigmentation. View Source ↗ Open source
4 Clinical Toxicology / Case Reports (PubMed) Rhabdomyolysis and severe sympathomimetic toxicity following a high (~6 mg) Melanotan II dose. View Source ↗ Open source
5 International Journal of Impotence Research (PubMed) Melanocortin (MC4R) agonism and erectile / sexual-arousal effects of Melanotan II. View Source ↗ Open source
6 U.S. Food & Drug Administration Consumer warning: Melanotan II is an unapproved drug; concerns over mole changes and melanoma risk. View Source ↗ Open source
7 Peptide Storage Guide Best practices for storing lyophilized peptides (temperature, humidity and light protection). View Source ↗ Open source
8 Bacteriostatic Water Guidance Bacteriostatic water for injection: multi-dose vial stability and handling. View Source ↗ Open source
9 NCBI Bookshelf Best practices for subcutaneous injection: aseptic technique and site rotation. View Source ↗ Open source
10 Injection Site Rotation (Patient Education) Guidance on rotating subcutaneous injection sites to prevent lipohypertrophy and irritation. View Source ↗ Open source
11 Aseptic Technique (CDC) Skin antisepsis and aseptic technique for injections. View Source ↗ Open source
14 Centers for Disease Control and Prevention (CDC) Subcutaneous injection technique: angle, site and no-aspiration guidance. View Source ↗ Open source
15 Subcutaneous Injection Technique (Patient Education) How to administer a subcutaneous injection: clinical technique guidelines. View Source ↗ Open source
16 Prime Lab Peptides Melanotan II (10 mg) product page — purity specifications and certificates of analysis. View Source ↗ Open source

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