HMG 75 IU

Important Note

This page is informational and does not authorize use. Peptify clients should complete assessment, disclose medications and health history, and follow the clinician-approved plan only.

Do not start, stop, combine, or change a protocol based only on website content.
Emergency symptoms require urgent medical care, not a website or routine follow-up message.

Quickstart Highlights

HMG (human menopausal gonadotropin / menotropins) is a urinary-derived gonadotropin preparation carrying roughly equal FSH and LH activity — FSH drives follicular growth in women and Sertoli-cell-supported spermatogenesis in men, while LH activity drives steroidogenesis (Leydig-cell testosterone in men)[1][2]. Menotropins (brand Menopur) is FDA-approved — but for controlled ovarian stimulation and ovulation induction in women. The thrice-weekly, hCG-combination male-fertility protocol outlined here is off-label clinical practice requiring physician oversight, and the research-grade vial described is not the licensed Menopur product. Presented for educational use only.

Add 3.0 mL bacteriostatic water to one 75 IU vial → 25 IU/mL for calculation convenience.
75 IU three times weekly (e.g. Mon/Wed/Fri) for 12 weeks (optionally 16), usually combined with hCG therapy.
At 25 IU/mL, a full 75 IU dose = 3.0 mL = 300 units — the entire vial, which exceeds a 1 mL insulin syringe. See the volume note below.
Lyophilized: refrigerate at 2–8 °C (35.6–46.4 °F); after reconstitution, use promptly or refrigerate and use within a few days.
Important: Start with the Prep & Injection Guide — it covers the preparation and safety basics every protocol on this site assumes.

Dosing & Reconstitution Guide

Off-label male-fertility reconstitution and thrice-weekly dosing, step by step

Male Fertility Protocol (3.0 mL = 25 IU/mL)

Phase / Week(s)	Dose per Injection	Volume (3.0 mL recon = 25 IU/mL)
Weeks 1–12	75 IU, 3×/week	3.0 mL (300 units) — full vial
Weeks 13–16 (optional extension)	75 IU, 3×/week	3.0 mL (300 units) — full vial

Reconstitute: Add 3.0 mL bacteriostatic water to one 75 IU vial → concentration 25 IU/mL.
Typical male protocol: 75 IU three times weekly (e.g. Monday, Wednesday, Friday) for 12 weeks, optionally extended to 16, usually combined with hCG therapy[3][5].
Unit math: on a U-100 syringe, 1 unit = 0.01 mL = 0.25 IU at this dilution. So 75 IU = 3.0 mL = 300 units, 25 IU = 1.0 mL = 100 units.
Storage: Lyophilized: refrigerate at 2–8 °C (35.6–46.4 °F); after reconstitution use promptly or refrigerate and use within a few days.
Important volume note: Each full 75 IU dose at 25 IU/mL is 3.0 mL = 300 units = the entire reconstituted vial, which exceeds standard 1 mL insulin-syringe capacity. Options: (1) use a 3 mL syringe for a single injection; (2) split the dose into three ~1 mL (25 IU) injections at different sites in one session; or (3) reconstitute in a smaller volume — e.g. 1.0 mL bacteriostatic water gives 75 IU/mL, so 1.0 mL = 100 units delivers the full dose[7].
Frequency: three subcutaneous injections per week, typically alongside hCG (2–3× weekly) to support testosterone and spermatogenesis[5][6]. These figures reflect off-label reference protocols, not approved male dosing.

Reconstitution Steps

Draw 3.0 mL bacteriostatic water with a sterile 3 mL syringe.

Inject slowly down the vial wall to avoid foaming.
Gently swirl or roll until fully dissolved — do not shake.
Label with date and time; refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
The 3.0 mL dilution gives a tidy 25 IU/mL for calculation convenience, but means a full dose fills the whole vial. If a smaller injection volume is preferred, a 1.0 mL reconstitution (75 IU/mL) lets the full 75 IU dose fit in a single 1 mL syringe (100 units). Use reconstituted solution promptly.
Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.

Supplies Needed

Quantities below assume a 12–16 week male-fertility course with thrice-weekly administration.

One full 75 IU dose uses an entire vial, so plan three vials per week.
12 weeks (3/week): ~36 vials
16 weeks (3/week): ~48 vials
A 3 mL syringe holds the full 3.0 mL dose. If using 1 mL insulin syringes for split dosing, multiply counts by 3.
Per week: 3 syringes
12 weeks: ~36 syringes
16 weeks: ~48 syringes
Use 3.0 mL per 75 IU vial for reconstitution.
12 weeks (36 vials): ~108 mL → ~11 bottles
16 weeks (48 vials): ~144 mL → ~15 bottles
One for the vial stopper + one for each injection site.
Per injection day: 2 swabs
12 weeks (3/week): ~72 swabs → 1 box
16 weeks (3/week): ~96 swabs → 1 box

Protocol Overview

A concise summary of the off-label thrice-weekly male-fertility regimen, drawn from clinical reference protocols.

▪Goal: Support spermatogenesis in men with hypogonadotropic hypogonadism or secondary infertility by supplying FSH activity alongside hCG — an off-label use, not an established benefit[3][5].
▪Schedule: Subcutaneous injections three times weekly for a minimum of 12 weeks, extendable to 16 weeks based on response[7].
▪Dose: 75 IU per injection, typically combined with hCG therapy[5][6].
▪Reconstitution: 3.0 mL bacteriostatic water per 75 IU vial gives 25 IU/mL for calculation convenience.
▪Storage: Lyophilized: refrigerate at 2–8 °C (35.6–46.4 °F); reconstituted solution used promptly or within a few days when refrigerated.

Dosing Protocol

Standard off-label male-fertility support approach.

▪Dose: 75 IU three times per week (e.g., Monday, Wednesday, Friday).
▪Combination therapy: Usually administered alongside hCG (2–3 times weekly) to support testosterone and spermatogenesis[5][6].
▪Cycle length: Minimum 12 weeks; may extend to 16 weeks based on response[7].
▪Route: Subcutaneous injection into fatty tissue (abdomen, thigh, or upper arm).
▪Timing: Maintain consistent injection days; rotate sites with each injection.

Storage Instructions

Proper storage maintains HMG stability and potency.

▪Lyophilized (unopened): Store at 2–8 °C (35.6–46.4 °F) away from light; stable at controlled room temperature up to 25 °C (77 °F)[8].
▪Reconstituted: Refrigerate at 2–8 °C; for best potency use promptly (official guidance recommends immediate use with plain diluent)[8].
▪With bacteriostatic water: Reconstituted solution may be refrigerated and used within a few days.
▪Light & disposal: Protect from light at all times; discard any unused solution if not used within the recommended timeframe.

Important Notes

Practical considerations for safe and consistent administration.

▪Combination therapy: Male protocols typically require concurrent hCG administration; HMG alone is not used to raise testosterone or boost fertility as an established benefit[5][6].
▪Sterile technique: Use a new sterile syringe for each injection and dispose in a puncture-proof sharps container[9].
▪Site rotation: Rotate sites (abdomen, thighs, upper arms) at least 1 inch apart to prevent lipohypertrophy or irritation.
▪Volume: The 3.0 mL injection volume may require a 3 mL syringe, splitting into smaller injections, or a smaller reconstitution volume.
▪Monitoring: Hormone therapy can disrupt the HPG axis — monitor semen parameters and hormone levels throughout under physician oversight. Clinical response typically takes at least 12 weeks; spermatogenesis may take 3–6 months to fully develop[7].
▪Regulatory note: Menotropins is FDA-approved for ovulation induction in women; male fertility use is off-label. Gonadotropins (S2.3) — and the co-therapy hCG — are WADA-prohibited in male athletes[10].

How This Works

HMG (human menopausal gonadotropin / menotropins) is a urinary-derived gonadotropin carrying roughly equal FSH and LH activity (standard preparations provide about 75 IU FSH + 75 IU LH per vial)[1][2].

FSH activity drives follicular growth in women and supports Sertoli-cell-mediated spermatogenesis in men; LH activity drives steroidogenesis — Leydig-cell testosterone production in men[1]. In men with hypogonadotropic hypogonadism, FSH is essential for spermatogenesis; when hCG alone fails to induce adequate sperm production, adding HMG supplies the FSH activity needed to support testicular function[3][5].
Clinical fertility literature reports that HMG combined with hCG can improve sperm parameters (motility, morphology, concentration) and pregnancy rates in treated couples[7]. These outcomes come from supervised clinical use, not from self-administered research-grade product.
Approval status: menotropins (brand Menopur) is FDA-approved — but for controlled ovarian stimulation and ovulation induction in women undergoing assisted reproduction. The thrice-weekly, hCG-combination male-fertility protocol on this page is off-label clinical practice requiring physician oversight and bloodwork, and the research-grade vial described here is not the licensed Menopur product. We do not claim it raises testosterone or boosts fertility as an established benefit in men.
Gonadotropin therapy can disrupt the hypothalamic-pituitary-gonadal (HPG) axis and is not appropriate for casual self-administration. Presented for educational purposes only.

Lifestyle Factors

Complementary habits that may support fertility outcomes alongside supervised therapy.

▪Nutrition & weight: Maintain a healthy body weight and a balanced diet rich in antioxidants (zinc, selenium, vitamins C and E).
▪Heat exposure: Avoid excessive heat to the testes (hot tubs, saunas, tight clothing).
▪Substances: Limit alcohol and avoid tobacco and recreational drugs.
▪Sleep & stress: Prioritize adequate sleep and manage stress; moderate exercise supports hormonal balance (avoid excessive endurance training).
▪Supplements: Consider coenzyme Q10, L-carnitine or other evidence-based supplements after consultation with a clinician.

Potential Benefits & Side Effects

Observations from clinical fertility literature; outcomes depend on supervised use and individual response.

▪Spermatogenesis support (off-label): May stimulate sperm production in men with hypogonadotropic hypogonadism or secondary infertility when combined with hCG[3].
▪Sperm parameters: Literature reports improved motility, morphology and concentration with HMG + hCG therapy[7].
▪Pregnancy rates: Increased pregnancy rates reported in couples undergoing supervised fertility treatment[7].
▪Note on men: These benefits are off-label and physician-supervised — HMG is FDA-approved for ovulation induction in women, not for raising testosterone or boosting male fertility as an established indication.
▪Injection-site reactions: Redness, swelling or mild pain; rotating sites helps.
▪Systemic effects: Headache, fatigue or mood changes (uncommon); gynecomastia from hormonal stimulation.
▪Overstimulation & allergy: Overstimulation effects if dosing is excessive (rare in men with proper monitoring); allergic reactions are rare — discontinue if hypersensitivity occurs.
▪Sport restriction: Gonadotropins (and co-therapy hCG) are WADA-prohibited in male athletes.

Injection Technique

General subcutaneous technique, following established clinical best-practice guidance[9].

▪Wash your hands thoroughly with soap and water and gather supplies on a clean surface.
▪Wipe the vial stopper with an alcohol swab and let it air-dry.
▪Draw the prescribed dose — a 3 mL syringe for the full 75 IU (3.0 mL) dose, or split across three 1 mL (25 IU) injections.
▪Select a site (lower abdomen at least 2 inches from the navel, outer thigh, or upper arm), clean it with a fresh alcohol swab and let it dry fully.
▪Pinch about an inch of skin to create a fold of subcutaneous tissue.
▪Insert the needle at a 90-degree angle (or 45 degrees if there is little subcutaneous fat).
▪Release the pinch and inject slowly over several seconds.
▪Withdraw the needle smoothly and apply gentle pressure with sterile gauze — do not rub the site.
▪Split-dose: If using 1 mL insulin syringes, divide the 3.0 mL total into three 1 mL injections (25 IU each) at different sites in the same session.
▪Dispose of the used syringe straight into a puncture-proof sharps container — never recap a needle.
▪Return the reconstituted vial to the fridge right away, protected from light.
▪Rotate the injection site each session, keeping at least 1 inch from previous sites to prevent irritation and lipohypertrophy.
▪Watch the site for excess redness, swelling, or signs of infection.

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References

Reference-derived details for HMG 75 IU.

HMG (75iu Vial) Dosage Protocol Open source
1 FSH + LH composition (menotropins) HMG is a urinary-derived gonadotropin with roughly equal FSH and LH activity; standard vials provide ~75 IU FSH + 75 IU LH. View Source ↗ Open source
2 Menopur (Menotropins) Product Monograph FDA-approved human menopausal gonadotropin for subcutaneous administration in controlled ovarian stimulation; ~75 IU FSH + 75 IU LH per vial. View Source ↗ Open source
3 Male hypogonadotropic hypogonadism (PubMed) Gonadotropin therapy for spermatogenesis in hypogonadotropic hypogonadism; FSH (HMG) added when hCG alone is insufficient. View Source ↗ Open source
4 ASRM Practice Committee – Gonadotropins for Ovulation Induction Clinical guidance on gonadotropin therapy; low-dose protocols (37.5-75 IU) with careful monitoring (approved use is in women). View Source ↗ Open source
5 HMG + hCG male fertility (PubMed) Combination gonadotropin therapy to support testosterone and spermatogenesis in men; off-label clinical practice. View Source ↗ Open source
6 Combination therapy outcomes (PubMed) HMG combined with hCG and reported effects on sperm motility, morphology and concentration. View Source ↗ Open source
7 Spermatogenesis timeline (PubMed) Clinical response to gonadotropin therapy typically requires 12+ weeks; spermatogenesis may take 3-6 months to develop. View Source ↗ Open source
8 Menotropins storage & handling Storage of lyophilized and reconstituted menotropins: refrigerate at 2-8 C, protect from light, use reconstituted solution promptly. View Source ↗ Open source
9 NCBI Bookshelf – Subcutaneous injection technique Best practices for subcutaneous injection: aseptic technique, angle and site rotation. View Source ↗ Open source
10 WADA Prohibited List Gonadotropins (S2.3) and the co-therapy hCG are prohibited in male athletes. View Source ↗ Open source
11 Prime Lab Peptides HMG (75 IU) research-grade product source – purity specifications and certificates of analysis. View Source ↗ Open source

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